RED CELLS Genetic endothelial systems biology of sickle stroke risk
نویسندگان
چکیده
1Vascular Biology Center and Division of Hematology-Oncology-Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis; 2Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis; 3Blood Research Institute, Children’s Research Institute, Medical College of Wisconsin, Milwaukee; 4Minneapolis Children’s’ Hospital and Department of Pediatrics, University of Minnesota Medical School, Minneapolis; 5Millennium Pharmaceuticals, San Francisco CA; and 6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis
منابع مشابه
Genetic endothelial systems biology of sickle stroke risk.
Genetic differences in endothelial biology could underlie development of phenotypic heterogeneity among persons afflicted with vascular diseases. We obtained blood outgrowth endothelial cells from 20 subjects with sickle cell anemia (age, 4-19 years) shown to be either at-risk (n=11) or not-at-risk (n=9) for ischemic stroke because of, respectively, having or not having occlusive disease at the...
متن کاملPerspectives Series: Cell Adhesion in Vascular Biology
The pathophysiologic hallmark of sickle cell disease is episodic occurrence of vasoocclusive events that precipitate acute painful episodes and lead, ultimately, to organ failure and death. Based upon studies from multiple laboratories over the last two decades, it is widely believed now that a key participant in this process may be the sickle erythrocyte’s predilection for adhesiveness to endo...
متن کاملRole of hydroxycarbamide in prevention of complications in patients with sickle cell disease
Sickle cell disease (SCD) is a genetically inherited condition caused by a point mutation in the beta globin gene. This results in the production of the abnormal hemoglobin, sickle hemoglobin (HbS). Hydroxycarbamide, is an antimetabolite/cytotoxic which works by inhibiting ribonucleotide reductase, blocking the synthesis of DNA and arresting cells in the S phase. In sickle cell anemia, it promo...
متن کاملHuman sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity.
OBJECTIVE Sickle cell disease (SCD) is characterized by extensive hemolysis, increased cellular adhesion, and vaso-occlusion. Tissues from sickle patients express heme oxygenase-1 (HO-1), the enzyme that degrades free heme/hemoglobin to the signaling molecule carbon monoxide, and the antioxidants biliverdin/bilirubin. Here, we examined the HO response in endothelial cells exposed to human sickl...
متن کاملIron Overload in Sickle Cell Disease
In sickle cell disease transfusions improve blood flow by reducing the proportion of red cells capable of forming sickle hemoglobin polymer. This limits hemolysis and the endothelial damage that result from high proportions of sickle polymer-containing red cells. Additionally, transfusions are used to increase blood oxygen carrying capacity in sickle cell patients with severe chronic anemia or ...
متن کامل